David Geffen School of Medicine at UCLA
Department of Human Genetics

Speaker Series - Winter Quarter 2011

Mondays, 11am - 12pm, Gonda Building First Floor Conference Room, 1357

Tue, Jan 11
Please note the seminar will take place at 3pm in CHS-73-105
The Epigenetic Basis of Common Human Disease
Andrew Feinberg, MD, MPH, King Fahd Professor of Molecular Medicine, Department of Medicine, Department of Oncology, & Department of Molecular Biology & Genetics, Johns Hopkins University School of Medicine
Contact & Intro: Julian Martinez, ext. 42405
Mon, Jan 24
What made us human?
Katherine Pollard, Ph.D., Associate Professor, Division of Biostatistics, UC San Francisco
Contact & Intro: Paivi Pajunkanta, ppajunkanta@mednet.ucla.edu
Mon, Jan 31
A Coalescent Model for Genotype Imputation Accuracy
Sebastian Zoellner, Ph.D., Assistant Professor, Biostatistics Department, University of Michigan
Contact & Intro: Janet Sinsheimer, ext. 58002
Thu, Feb 03
Please note the seminar will take place at 1:30pm
Analysis and Replication of Complex Trait Rare Variant Association Studies: Application to Second Generation Sequence Data
Suzanne Leal, Ph.D., Professor, Department of Molecular & Human Genetics, Baylor College of Medicine
Contact & Intro: Rita Cantor, x72440
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ABSTRACT: There is overwhelming evidence that rare variants play an important role in complex disease etiology. Although published rare variant association studies have been limited to a few complex trait candidate gene studies, currently many studies are generating exome sequence data using second generation sequencing in order to detect rare variant complex trait associations. Association methods used to analyze common variants should not be used for the analysis or rare variants since they are grossly underpowered. Instead methods which have been developed to test for association with rare variants which rely on aggregating information on rare variants within a region, e.g. gene should be used. Once associations are detected it is important to replicate the findings in an independent sample, since findings can be false positives even if the family wise error rate is well controlled. Additionally spurious associations can occur due to improperly controlling for population admixture/substructure and sequencing errors. Methods to analyze rare variant association data for complex traits will be presented and their power will be compared for a variety of underlying genetic models. Additionally strategies for gene-based replication will be compared in particular whether variant-based replication is sufficiently powered or sequence-based replication is necessary.

Mon, Feb 14
Systems Genetics Analysis of Macrophage Inflammatory Responses
Luz Orozco, Department of Human Genetics, UCLA
Contact & Intro: Kate Wheeler, kwheeler@mednet.ucla.edu
Fri, Feb 18
Please note the seminar will take place at 2:30pm
Interaction of Host, Commensal Microbiota, and Pathogens: Applying the Multi-Omics Approach
Hiroshi Ohno, Head, Laboratory for Epithelial Immunobiology Research Institute for Allergy and Immunology, RIKEN
Contact & Intro: Esteban Dell'Angelica, x63749
Mon, Mar 07
Angela Stathopoulos, Ph.D., Assistant Professor of Biology, California Institute of Technology
Contact & Intro: Kate Wheeler, x72487
Mon, Mar 14
Human population structure in the genomic era: rare variants and ancestry-switch points
John Novembre, Ph.D., Assistant Professor, Department of Ecology & Evolutionary Biology, UCLA
Contact & Intro: Kate Wheeler, kwheeler@mednet.ucla.edu

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