David Geffen School of Medicine at UCLA
Department of Human Genetics

Speaker Series - Fall Quarter 2017

Mondays, 11am - 12pm, Gonda Building First Floor Conference Room, 1357

Mon, Oct 09
Causes and Consequences of Human Genomic Variation
Sohini Ramachandran, PhD; Associate Professor of Ecology and Evolutionary Biology; Associate Professor of Computer Science; Director, Center for Computational Molecular Biology; Brown University
Contact & Intro: Jazlyn Mooney
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ABSTRACT: Determining the genomic elements underlying adaptive evolution and diseases in a species is essential for connecting genetic variation to phenotypes and fitness, but current statistical methods overlook the confounding effect population histories have on the identification and localization of adaptive and disease-associated mutations. I'll discuss two methods developed in my laboratory that (i) model the complex interaction between various modes of selection and population histories; and (ii) accurately identify and localize mutations, genes, and pathways underlying adaptive traits and disease for further experimental validation. These methods can be extended and applied to existing and emerging genome-wide polymorphism and next-generation sequencing datasets for humans and a range of other organisms. Our goal is to yield new insight into the interaction between selection and dynamic population histories in generating human genetic diversity and the human phenotype.

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