Hum Gen 236b: Advanced Human Genetics
Session 7: Population
genetics with implications for association mapping
The goal of these lectures is to introduce the students to some basic concepts of population genetics and their relevance for genetic mapping.
In reading through the class notes, please make sure you retain:
- Definition of Hardy-Weinberg equilibrium
- Definition of Linkage equilibrium
- Definition of selection
- Definition of genetic drift
- Difference in behavior over time of deviances from equilibrium for HW and linkage.
- Appropriate statistical tests for HW
- Appropriate statistical tests for linkage equilibrium
- Measures of linkage disequilibrium
- Role of linkage disequilibrium in association studies