We would like to acknowledge the grant support from NINDS/NIMH 1U24NS043562-01 (PI Stanley Nelson) and Program Project on "genomics for kidney transplantation" (PI Dan Salomon) grant number: 1U19AI063603-01. We are grateful for discussions with our UCLA collaborators Marc Carlson, Jun Dong, Dan Geschwind, Jake Lusis, Ai Li, Paul Mischel, Stanley Nelson,and Andy Yip.