Network image ICSB 2007 logo

Gene Co-Expression Network Analysis
and its Applications in Systems Biology


Workshop within the 8th International Conference on Systems Biology

October 5th, 2007, 8:50 AM - 5:30 PM
Seaview A, Hyatt Regency Hotel, Long Beach
(adjacent to the Convention Center)





Workshop agenda

Gene co-expression networks are increasingly used to analyze gene expression data (microarrays). Co-expression networks facilitate a systems level view of the transcriptome that moves beyond lists of differentially expressed genes, hence providing a natural bridge between individual genes and systems level approaches. Subsets of highly connected genes (modules) may correspond to biologically or clinically important pathways. A module-centric view allows one to study properties of and relationships among biological processes, molecular functions etc. In this workshop, we discuss recent and future work regarding the use of gene co-expression networks for 

and other applications.

We also discuss theoretical properties of the methods and important open research questions. This workshop should be of interest to systems biologists, systems geneticists, computational biologists, bioinformaticians, statisticians, mathematicians, and other quantitative types.

While this workshop focuses on gene co-expression network methods, many of the results (e.g., module detection, topological properties of networks, etc.) also pertain to networks in various other settings.

Workshop venue and format

The workshop will be held in room Seaview A of the Hyatt Regency hotel in Long Beach, on October 5th, 2007, starting at 8:50 AM and ending around 5:30 PM. Program details are provided below. A detailed floorplan as well as directions to the hotel are available here (pdf format).

Each talk will be allotted 25 minutes plus 5 minutes for questions. The list of speakers with titles of their talks and abstracts is provided below.

Organizers

Peter Langfelder and Steve Horvath, Dept. of Human Genetics, UC Los Angeles. You can email us at {plangfelder, shorvath} at mednet.ucla.edu

Program

(click on linked titles to see abstracts; where available, slides can be downloaded in Powerpoint (PPT) of Adobe PDF form)

8:50 Workshop opening
9:00 Xianghong Jasmine Zhou (USC) Functions, Networks, and Phenotypes by Integrative Genomics Analysis Slides:
PDF
9:30 Grace Shieh (Institute of Statistical Science, Academia Sinica) A Pattern Recognition Approach to Infer Genetic Networks from Microarray Data
10:00 Coffee break
10:15 Eivind Almaas (LLNL) Network approaches and microbial metabolism
10:45 Michael Oldham (UCLA) Functional organization of the transcriptome in human brain
11:15 Peter Langfelder (UC Los Angeles) Consensus eigengene networks: Studying relationships between gene co-expression modules across networks Slides:
PPT, PDF
11:45 Lunch (individual)
1:30 Jason Wilson (UC Riverside) On the probability of correct selection for large k populations, with application to Microarray Data
2:00 Fengzhu Sun (USC) Integrated Approaches for Gene Discovery
2:30 Eric Xing (Carnegie Mellon University) Inferring Dynamically Evolving Networks
3:00 Coffee break
3:15 Michael Mason (UC Los Angeles) Signed Weighted Gene Coexpression Network Analysis Slides:
PPT, PDF
3:45 Tova Fuller (UC Los Angeles) Differential Weighted Gene Coexpression Network Analysis Applied to Mouse Weight Slides:
PPT, PDF
4:15 Liang Chen (USC) Cp Considering Dependency among Genes and Markers for False discovery Control in eQTL Mapping
4:45 Group discussion: outstanding problems in gene co-expression network analysis, future directions


Partial list of other participants

  • Wei Zhao (St Jude Children's Research Hospital) (*)
  • Angela Presson (UC Los Angeles)
  • Stephen Edwards (U.S. Environmental Protection Agency)
  • Sarah Stockwell (Cornell)
  • Hairong Wei (Wicell Research Institute)
  • Wen Lin (UC Los Angeles)
  • Ann Loraine (University of Alabama at Birmingham)
  • Jun Dong (UC Los Angeles)
  • Joshua Ho (University of Sydney)
  • Henrik Joensson (Lund University)
  • Steve Horvath (UC Los Angeles)
(*) To be confirmed.

Travel and local information

For travel and local information, please consult the appropriate pages of the ICSB 2007 web site.


Page by Peter Langfelder. Gene network image courtesy of Jake Lusis Lab; ICSB logo courtesy of ICSB 2007.

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