Rita Cantor Ph.D.
Mathematical modeling of human disease traits.
Stephen Cederbaum M.D.
Identification, cloning, regulation and evolution of the two arginases, AI and AII, in man and experimental animals. The goal is to understand the basic biology and pathology of arginine metabolism and then find a treatment for arginase AI deficiency.
Esteban Dell Angelica Ph.D.
Genetic Disorders of Organelle Biogenesis and Protein Trafficking
Katrina Dipple M.D., Ph.D.
Glycerol kinase deficiency, inborn errors of metabolism, molecular basis of disease
Eleazar Eskin Ph.D.
Bioinformatics, Genomics, Computational Methods for Analysis of Complex Traits.
Guoping Fan Ph.D.
Molecular and cellular mechanisms underlying neuronal differentiation; and generation of mouse models for human diseases.
Jonathan Flint Ph.D.
Understanding how genes influence behaviour, in particular how genetic variation contributes to disease susceptibility
Brent Fogel M.D., Ph.D.
Basic and fundamental molecular mechanisms underlying human neurodevelopment and neurodegenerative disease.
Nelson Freimer M.D.
Genetic basis of complex traits, particularly neurobehavioral disorders including bipolar disorder, schizophrenia, depression, and Tourette Syndrome.
Wayne Grody M.D., Ph.D.
Regulation of gene expression in the human arginase system and arginase deficiency; role of arginase in cancer cell proliferation; technical and ethical aspects of molecular genetic screening; development of novel DNA diagnostics.
Steve Horvath Ph.D.
Allelic Association Studies and Microarray Data Analysis
Leonid Kruglyak Ph.D.
Genetic Basis of Phenotypic Variation
James Lake Ph.D.
Genomics and genome evolution
Kenneth Lange Ph.D.
Formulation of statistical methods for analyzing the genetic basis of common diseases
Jingyi Jessica Li Ph.D.
Statistical methods in biology and genomics, Sparse linear modeling and Bioinformatics
Kirk Lohmueller Ph.D.
Population genetics and genomics
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Aldons J. Lusis Ph.D.
Genetics of complex diseases such as atheroschlerosis using inbred animal strains as models
Julian A. Martinez-Agosto M.D., Ph.D.
Genetics of growth signaling pathways in stem cells, cancer and overgrowth syndromes
Stanley Nelson M.D.
Technology development for the analysis of complex traits: development of microarrays to study gene expression and SNP scoring
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Roel Ophoff Ph.D.
Genetics of neuropsychiatric traits
Päivi Pajukanta M.D., Ph.D.
Genetics of cardiovascular diseases
Jeanette Papp Ph.D.
Bioinformatic solutions for the management and analysis of all types of genetic data
Bogdan Pasaniuc Ph.D.
Statistical and computational methods for understanding genetic risk factors for common diseases, particular focus in the study of admixed populations
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Matteo Pellegrini Ph.D.
Development of computational approaches to interpret genomic data
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Joseph Pisegna M.D.
Molecular pharmacology of hormones and receptors in the gastrointestinal tract, diagnosis and management of islet cell tumors of the pancreas
Karen Reue Ph.D.
Genes underlying disorders in lipid and glucose metabolism.
Jerome Rotter M.D.
Genetics of complex diseases: inflammatory bowel disease, atherosclerosis, diabetes
Janet Sinsheimer Ph.D.
Mathematical models of evolution and genetics.
Eric Sobel Ph.D.
Statistical genetics methodologies for large pedigrees
Sriram Sankararaman Ph.D.
Novel methods to analyze large-scale genomic data to understand how genetic variation leads to phenotypic variation
Marc Suchard M.D., Ph.D.
Mathematical and statistical phylogenetics, evolutionary medicine, computational biology, Bayesian methods
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Eric Vilain M.D., Ph.D.
Genetics of sex determination and development of the human reproductive system
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Stephen Young M.D.
During the past few years, we have worked on two general areas, the pathogenesis of hypertriglyceridemia and diseases of the nuclear lamina. Our laboratory works on molecules as they relate to human disease, and we make use of diverse techniques in molecular and cellular biology. When appropriate, we make use of genetically modified mice to investigate our research questions.